Developmental Programming and Disease: Environmental Risk Factors, Mechanisms and Strategies Workshop
The Department of Environmental Medicine and the UR Environmental Health Science Center are holding a workshop on Developmental Programming of Disease, an increasingly recognized basis for diseases and disorders that occur throughout life. The workshop will focus on current understanding of mechanisms that underlie early life programming, ranging from glucocorticoids, germ cell imprinting, immune cell programming, the gut microbiome and nutrition. The morning session will include presentations of cutting edge research, and the afternoon session will include breakout group discussions addressing interrelated issues, including limitations of our current understanding, cumulative exposure/stressors, intervention/prevention approaches and future research directions. These discussions will be shared back to the group at large, and the workshop will end with a wine and cheese reception.
The workshop is open to all, and is free. Registration is requested to help us have the correct amount of refreshments.
8:30 - 8:45 am Early Life programming in the Rochester Environmental Health Science Center and purpose of the workshop
8:45 - 9:30 am Jerry Heindel: Introduction to Early Life Programming by Exogenous Factors
9:30 - 10:00 am Rebecca Fry: TBD
10:00 - 10:20 am Coffee Break
10:20 - 10:50 am Derrick MacFabe: The role of the gut microbiome in fetal programming
11:00 - 11:30 am Edwin van Wijngaarden: Mercury exposure from life-long fish consumption and developmental outcomes: Thirty years of data from the Seychelles Child Development Study
11:30 - 12:00 pm Martha Susiarjo: Fetal imprinting as a mechanism of programming
12:00 - 12:30 pm Kristen Scheible: Immune cell programming in respiratory outcomes
12:30 - 1:30 pm Lunch
1:30 - 2:00 pm Margot Mayer Proschel: Early nutrition and fetal programming
2:00 - 3:00 pm Breakout Groups to discuss the following questions or other topics that arise
- What are critical (but addressable) limitations of current understanding?
- What are some future research directions that we could make an impact on in Rochester?
- How to move forward and also better integrate research in model systems and human populations
- What are innovative ways to test potential intervention and/or prevention approaches?
- What are some new strategies to better understand cumulative exposures and mixtures of environmental stressors
3:00 - 4:00 pm Share Back from breakout groups
4:00 - 5:30 pm Reception