The OneFlorida Clinical Research Consortium represents a strategic integration and expansion of CTSA hub partnerships throughout Florida to create a statewide infrastructure for patient-centered research in diverse health care settings. Consortium partners include the University of Florida, Florida State University, University of Miami and affiliated health care systems, health plans, providers and patients. Together, OneFlorida partners provide health care to more than half of Floridians in all 67 counties of the nation’s third-largest state, encompassing private, public and academic health care systems and hospitals. The consortium’s data trust and practice-based research network provide an infrastructure for large-scale pragmatic clinical trials, implementation science studies and comparative effectiveness research, supported by various funding agencies. As a Clinical Data Research Network supported by the Patient-Centered Outcomes Research Institute, OneFlorida bridges both the CTSA consortium and PCORnet. The UF Clinical and Translational Science Institute serves as the OneFlorida coordinating center.