CTSA Visiting Scholar Program

Duke CTSI

KL2 awardees from Clinical and Translational Science Centers (CTSA) present virtual lectures as part of the CTSA Visiting Scholar Program. Duke University will host Ankit Shah, MD, Assistant Professor of Medicine, Division of Endocrinology, Diabetes and Metabolism, Rutgers University. Dr. Shah will present "Glycerol as a Direct and Indirect Contributor to Glucose Production."

Despite current treatments, hyperglycemia remains a persistent and progressive problem for patients with type 2 diabetes mellitus (T2DM) and is driven in part by increased hepatic gluconeogenesis as the liver combines smaller non-carbohydrate precursors to form a six-carbon glucose molecule. Many consider lactate the predominant carbon contributor to gluconeogenesis though our published animal studies and preliminary human data show glycerol is a significant contributor by supplying carbons independently to both glucose and lactate. This presentation will review the use of stable isotope tracer infusion and metabolomics analysis with mass spectrometry in animal and preliminary human studies which describe show as a more prominent contributor to T2DM hyperglycemia than currently appreciated. Ongoing research efforts could posit glycerol as a novel therapeutic target for T2DM not currently use by current treatments.

Date
- Add to Calendar 2021-04-09 13:00:00 2021-04-09 14:00:00 CTSA Visiting Scholar Program Register Here https://duke.qualtrics.com/jfe/form/SV_6fHVD4viozeoF2l

KL2 awardees from Clinical and Translational Science Centers (CTSA) present virtual lectures as part of the CTSA Visiting Scholar Program. Duke University will host Ankit Shah, MD, Assistant Professor of Medicine, Division of Endocrinology, Diabetes and Metabolism, Rutgers University. Dr. Shah will present "Glycerol as a Direct and Indirect Contributor to Glucose Production."

Despite current treatments, hyperglycemia remains a persistent and progressive problem for patients with type 2 diabetes mellitus (T2DM) and is driven in part by increased hepatic gluconeogenesis as the liver combines smaller non-carbohydrate precursors to form a six-carbon glucose molecule. Many consider lactate the predominant carbon contributor to gluconeogenesis though our published animal studies and preliminary human data show glycerol is a significant contributor by supplying carbons independently to both glucose and lactate. This presentation will review the use of stable isotope tracer infusion and metabolomics analysis with mass spectrometry in animal and preliminary human studies which describe show as a more prominent contributor to T2DM hyperglycemia than currently appreciated. Ongoing research efforts could posit glycerol as a novel therapeutic target for T2DM not currently use by current treatments.

https://clic-ctsa.org/events/ctsa-visiting-scholar-program Duke University admin@clic-ctsa.org America/New_York public
Activity Type
Special Event
Organization
Location Type
Online
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