Mayo Clinic Center for Clinical and Translational Science
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ClaudiaLucchinettiPhysician Scientist; Professor of Neuroscience; Department Chair NeurologyUL1 Administrator
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ClaudiaLucchinettiPhysician Scientist; Professor of Neuroscience; Department Chair Neurology
Consortium News
A Rochester company that developed a device that reduces the size of eye droplets by 60% won the grand prize of the Minnesota Cup on Monday night, beating nearly 2,000 other companies that entered what has become the largest statewide competition for startups in Minnesota. Led by a Mayo Clinic medical student, Nanodropper Inc. won the $50,000 grand prize, in addition to $25,000 for winning its
The microscope hovers over a small dish. It's attached to a laptop, so students don't need to press their faces against a microscope eyepiece. On the screen is a zebrafish egg. On hand to answer questions are scientists. The questions, however, are a little different from the ones they get from colleagues. "One of the questions I got was how does gravity work, and I was like, 'Oh that's a great
Beriberi, which affects metabolic, neurologic, cardiovascular, respiratory, gastrointestinal and musculoskeletal systems, was largely eradicated in developed countries more than 70 years ago. Over the past 20 years, Philip Fischer, M.D., has been engaged in health disparities research to find ways to do the same in countries where the disease persists today.
Educational Content
Fundamentals of Clinical and Translational Science (FunCaTS) is a combination of 13 online modules strategically packaged together to enable medical professionals and allied health staff to expand their knowledge of the components of clinical and translational research. These components provide the fundamental knowledge to promote understanding of the process of bringing discoveries to the bedside
Are you ready to take a deeper dive into the world of clinical and translational science? Essentials of Clinical and Translational Science (ECaTS) provides medical professionals with foundational knowledge of research terminology, research methods and processes, clinical epidemiology, and biomedical statistics. Upon completion, learners understand basic terminology and methodological concepts in
Are you ready to take a deeper dive into the world of clinical and translational science? Essentials of Clinical and Translational Science (ECaTS) provides medical professionals with foundational knowledge of research terminology, research methods and processes, clinical epidemiology, and biomedical statistics. Upon completion, learners understand basic terminology and methodological concepts in
Events
Sjӧgren's syndrome (SS), the second most common rheumatic disease contributing nine times the cost of a healthy person, has hallmark features of oral and ocular dryness due to salivary and lacrimal gland inflammation. Minor salivary glands, central to the pathogenesis and diagnosis of SS, contain mesenchymal stromal cells (MSCs). In other conditions MSCs are responsible for tissue repair and
Almost all cardiovascular variables that have been assessed at different times of day and night in humans have been found to have a day/night pattern, including blood pressure heart rate, and vascular endothelial function. These patterns result from the summation of predictable circadian effects with variable behavioral (e.g. sleep, exercise, and meal intake) and environmental (e.g. temperature)
Opportunities
Charge The Director of Continuous Quality Improvement and Program Evaluation for the Mayo Clinic College of Medicine and Science (MCCMS) provides strategic and operational direction to implement a comprehensive, integrated and sustainable quality improvement and evaluation system across the College. This system should provide each school within MCCMS with ready access to the synthesis of key data
Poster Sessions
The Mayo Clinic COVID-19 Task Force was established to enable, coordinate, and catalog research studies and practice demands of COVID-19. The task force manages research across the whole translational spectrum, aligning competing and duplicative studies to steward research resources and coordinates Institutional Review Board, Center for Clinical and Translational Science (CCaTS) Office of Clinical
Many clinical questions have arisen with the COVID-19 pandemic, from who is at greatest risk for COVID-19 infection to adverse outcomes if infected to how COVID-19 has impacted healthcare utilization patterns. To help answer these questions, and many more, the National COVID Cohort Collaborative (N3C) has integrated real-world clinical observations from across the nation into a harmonized database
The Office of Translation to Practice (OTP) is housed in the Center for Clinical and Translational Sciences at Mayo Clinic. Established in 2015, the office is tasked with developing and managing novel tools, mechanisms, and processes to facilitate and accelerate the translation of products, such as drugs, biological agents, and medical devices, into practice. Since its inception, OTP is credited
Publications
Higher unacylated ghrelin and insulin sensitivity following dietary restriction and weight loss in obese humans
Unacylated ghrelin (UnAG) modulates insulin sensitivity. Low plasma UnAG occurs in obesity and potentially contributes to obesity-associated insulin resistance. We hypothesized that improvements in insulin sensitivity in obese people induced by moderate caloric restriction (CR) may be paralleled and
Regulation of direct adipose tissue free fatty acid storage during mixed meal ingestion and high free fatty acid concentration conditions
We found that direct free fatty acid (FFA) storage (fatty acid cycling back into adipose tissue) in leg vs. abdominal subcutaneous fat is related to regional differences in adipose tissue diacylglycerol acyltransferase (DGAT) activity under high-FFA conditions and to differences in adipose tissue
Timeline of Rapid Eye Movement Sleep Behavior Disorder in Overt Alpha-Synucleinopathies
The aim was to analyze the timeline, prevalence, and survival of rapid eye movement (REM) sleep behavior disorder (RBD) in patients who developed alpha-synucleinopathies (Parkinson disease, dementia with Lewy bodies, and Parkinson disease dementia) compared with age- and sex-matched controls in a
Research and Operational Tools
The Rochester Epidemiology Project (REP) is a collaboration between health care providers in Minnesota and Wisconsin.
Clinical trials bridge the gap between research and patient care and help a medical discovery become a therapy. The clinical trial journey is long and complicated, with many steps along the way, and it can be challenging to describe this process to patients and research volunteers, or to colleagues who are unfamiliar with clinical research.