Mayo Clinic Center for Clinical and Translational Science
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UL1 Director
ClaudiaLucchinettiPhysician Scientist; Professor of Neuroscience; Department Chair NeurologyUL1 Administrator
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KL2 Director
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Methods and Processes Voting Member
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ClaudiaLucchinettiPhysician Scientist; Professor of Neuroscience; Department Chair Neurology
Consortium News
Somali and Latino immigrants lost weight when they worked together in culturally specific groups and received coaching by someone from their community. The Mayo Clinic’s pilot study was such a success it’s being replicated on a larger scale.
Editor's note: Mayo Clinic advances health equity by collaborating with communities in research that addresses their health concerns and aims to reduce health disparities. This article is the third in the Raising Up Community Voices in Research series. This series is written by community members who collaborate with Mayo Clinic on community-driven medical research. In this essay, Eula Saxon Dean
During the COVID-19 pandemic, many people's lives were disrupted, and isolation increased. And with that isolation came weight gain. The Centers for Disease Control and Prevention says children and adults have gained weight during the pandemic, stressing that obesity worsens COVID-19 outcomes. However, a recent Mayo Clinic community-based pilot study suggests that weight gain can be prevented and
Educational Content
Fundamentals of Clinical and Translational Science (FunCaTS) is a combination of 13 online modules strategically packaged together to enable medical professionals and allied health staff to expand their knowledge of the components of clinical and translational research. These components provide the fundamental knowledge to promote understanding of the process of bringing discoveries to the bedside
Are you ready to take a deeper dive into the world of clinical and translational science? Essentials of Clinical and Translational Science (ECaTS) provides medical professionals with foundational knowledge of research terminology, research methods and processes, clinical epidemiology, and biomedical statistics. Upon completion, learners understand basic terminology and methodological concepts in
Are you ready to take a deeper dive into the world of clinical and translational science? Essentials of Clinical and Translational Science (ECaTS) provides medical professionals with foundational knowledge of research terminology, research methods and processes, clinical epidemiology, and biomedical statistics. Upon completion, learners understand basic terminology and methodological concepts in
Events
The CTSA Visiting Scholar program consists of giving the virtual CTSA Grand Rounds lecture, which is open to the entire CTSA Consortium, and virtual meetings between KL2 Scholars and faculty at the host institution and their KL2 peers. There are two main goals of this program. The first is to offer the opportunity to serve as a visiting professor and help make connections with faculty that will
The CTSA Visiting Scholar program consists of giving the virtual CTSA Grand Rounds lecture, which is open to the entire CTSA Consortium, and virtual meetings between KL2 Scholars and faculty at the host institution and their KL2 peers. There are two main goals of this program. The first is to offer the opportunity to serve as a visiting professor and help make connections with faculty that will
Sjӧgren's syndrome (SS), the second most common rheumatic disease contributing nine times the cost of a healthy person, has hallmark features of oral and ocular dryness due to salivary and lacrimal gland inflammation. Minor salivary glands, central to the pathogenesis and diagnosis of SS, contain mesenchymal stromal cells (MSCs). In other conditions MSCs are responsible for tissue repair and
Opportunities
Charge The Director of Continuous Quality Improvement and Program Evaluation for the Mayo Clinic College of Medicine and Science (MCCMS) provides strategic and operational direction to implement a comprehensive, integrated and sustainable quality improvement and evaluation system across the College. This system should provide each school within MCCMS with ready access to the synthesis of key data
Poster Sessions
Objectives: To assess the impact of the COVID-19 pandemic on clinical research and the use of electronic approaches to mitigate this impact. Methods: We compared the utilization of electronic consenting, remote visits, and remote monitoring by study monitors in all research studies conducted at Mayo Clinic sites (Arizona, Florida, and Minnesota) before and during the COVID-19 pandemic (ie, between
The Mayo Clinic COVID-19 Task Force was established to enable, coordinate, and catalog research studies and practice demands of COVID-19. The task force manages research across the whole translational spectrum, aligning competing and duplicative studies to steward research resources and coordinates Institutional Review Board, Center for Clinical and Translational Science (CCaTS) Office of Clinical
Many clinical questions have arisen with the COVID-19 pandemic, from who is at greatest risk for COVID-19 infection to adverse outcomes if infected to how COVID-19 has impacted healthcare utilization patterns. To help answer these questions, and many more, the National COVID Cohort Collaborative (N3C) has integrated real-world clinical observations from across the nation into a harmonized database
Publications
Timeline of Rapid Eye Movement Sleep Behavior Disorder in Overt Alpha-Synucleinopathies
The aim was to analyze the timeline, prevalence, and survival of rapid eye movement (REM) sleep behavior disorder (RBD) in patients who developed alpha-synucleinopathies (Parkinson disease, dementia with Lewy bodies, and Parkinson disease dementia) compared with age- and sex-matched controls in a
Higher unacylated ghrelin and insulin sensitivity following dietary restriction and weight loss in obese humans
Unacylated ghrelin (UnAG) modulates insulin sensitivity. Low plasma UnAG occurs in obesity and potentially contributes to obesity-associated insulin resistance. We hypothesized that improvements in insulin sensitivity in obese people induced by moderate caloric restriction (CR) may be paralleled and
Regulation of direct adipose tissue free fatty acid storage during mixed meal ingestion and high free fatty acid concentration conditions
We found that direct free fatty acid (FFA) storage (fatty acid cycling back into adipose tissue) in leg vs. abdominal subcutaneous fat is related to regional differences in adipose tissue diacylglycerol acyltransferase (DGAT) activity under high-FFA conditions and to differences in adipose tissue
Research and Operational Tools
The Rochester Epidemiology Project (REP) is a collaboration between health care providers in Minnesota and Wisconsin.
Clinical trials bridge the gap between research and patient care and help a medical discovery become a therapy. The clinical trial journey is long and complicated, with many steps along the way, and it can be challenging to describe this process to patients and research volunteers, or to colleagues who are unfamiliar with clinical research.