The University of Florida Clinical and Translational Science Institute and its CTSA hub partner, Florida State University, serve as a catalytic hub connecting resources, people and ideas across the state and the CTSA consortium. The CTSI amplifies the capabilities of individual and team investigators, and helps them more effectively and more quickly carry out clinical and translational research. The CTSI performs three central functions: 1) transforms and continuously improves the research environment by developing new capabilities for research and translation to practice; 2) delivers high-quality and efficient services and resources for translational research; and 3) cultivates a strong translational workforce. In 2013, the CTSI led creation of the OneFlorida Clinical Research Consortium in collaboration with FSU, the University of Miami CTSA hub and other stakeholders to extend the impact and reach of translational science throughout the nation’s third-largest state.