The University of Illinois at Chicago (UIC) Center for Clinical and Translational Science (CCTS) seeks to catalyze translational research, locally and nationally, as part of a national network to improve individual and population health. Since our initial funding by the NIH in 2009, the CCTS has been a catalyst for mobilizing institutional support and resources to enhance clinical translational research and expand multidisciplinary training programs to increase workforce diversity and promote team science. The overarching goal—and driving focus—of the CCTS is to improve population health, particularly among minorities and underserved populations. Our high-quality multidisciplinary clinical and translational research, spanning T1-T4 and paired with strengths in community engagement and implementation science and appreciation for the social determinants of health, help to accelerate discoveries into practice and policy.