University of Texas Health Science Center Houston

UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

Mission Statement

The goal of the Center for Clinical and Translational Sciences (CCTS) is to facilitate clinical and translational research at The University of Texas Health Science Center at Houston (UTHealth), The University of Texas M. D. Anderson Cancer Center, and the Memorial Hermann Hospital System.

At a Glance

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Educational Resources Posted

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Consortium News Stories Posted

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Events Posted

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Opportunities Posted

125

Publications citing CTSA Program Grant

23

Users from Hub Registered
Programs

UL1 Award

KL2 Award

TL1 Award

Funded Years
2012 - 2016, 2019 - 2021

Poster Sessions

University Of Texas Hlth Sci Ctr Houston

Clinical and research data are increasingly collected and aggregated in clinical data warehouses (CDWs). Access to these data is subject to local, state and national regulations. For multiple reasons, institutions differ in how they interpret and apply these regulations. Sometimes, inter-institutional differences are unavoidable, such as when regulations clearly require specific practices. However

University Of Texas Hlth Sci Ctr Houston

There has been a true revolution in cancer treatment. Numerous genetic alterations are being targeted using new therapies with the potential for improved, less toxic – often durable - outcomes in advanced cancer. Response rates are 3-5% for unmatched treatment with new tyrosine kinases and other similar agents whereas a “high value” alteration can result in response rates of 30-50% for actionable

Learning Healthcare: An Ongoing Paradigm Shift
University Of Texas Hlth Sci Ctr Houston

Learning healthcare (LHC) incorporates learning seamlessly into everyday patient care and is crucial to rapidly advancing patient outcomes and ultimately population health. Observational studies are valuable in generating new hypotheses and identifying highly effective therapies (resulting in a published relative risk for adverse outcome <0.10 compared to placebo or usual care). However, the great

Publications

Associations of Metabolic Genes (GSTT1, GSTP1, GSTM1) and Blood Mercury Concentrations Differ in Jamaican Children with and without Autism Spectrum Disorder

We investigated interactive roles of three metabolic glutathione S-transferase (GST) genes (GSTP1, GSTT1, and GSTM1) and autism spectrum disorder (ASD) status in relation to blood Hg concentrations (BHC) of Jamaican children. We used data from 266 children (2-8 years) with ASD and their 1:1 age- and

Large-Scale Characterization of Drug Responses of Clinically Relevant Proteins in Cancer Cell Lines

Perturbation biology is a powerful approach to modeling quantitative cellular behaviors and understanding detailed disease mechanisms. However, large-scale protein response resources of cancer cell lines to perturbations are not available, resulting in a critical knowledge gap. Here we generated and

Potential caveats of putative microglia-specific markers for assessment of age-related cerebrovascular neuroinflammation

The ability to distinguish resident microglia from infiltrating myeloid cells by flow cytometry-based surface phenotyping is an important technique for examining age-related neuroinflammation. The most commonly used surface markers for the identification of microglia include CD45 (low-intermediate