UW Medicine

Mission Statement

The Institute of Translational Health Sciences is dedicated to speeding science to clinic practice for the benefit of patients and communities throughout Washington, Wyoming, Alaska, Montana, Idaho (WWAMI), and beyond. ITHS promotes this translation of scientific discovery to practice by fostering innovative research, cultivating multi-disciplinary research partnerships, and ensuring a pipeline of next generation researchers through robust educational and career development programs. In the past, individual groups looked at health issues only from their perspective. We now realize that partnerships between scientists, clinicians, and communities are needed to tackle complex health issues. The ITHS is a partnership between the University of Washington, Fred Hutchinson Cancer Research Center, and Seattle Children’s. We also collaborate with regional institutions, providers, and community organizations across the five-state WWAMI region.</p>

At a Glance

1

Educational Resources Posted

5

Consortium News Stories Posted

5

Events Posted

0

Opportunities Posted

356

Publications citing CTSA Program Grant

50

Users from Hub Registered
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Programs

UL1 Award

KL2 Award

TL1 Award

Funded Years
2012 - 2021

Consortium News

Amy Lasek, a former UIC Center for Clinical and Translational Science pilot grant awardee (2018-2020) and researcher at UIC’s Center for Alcohol Research in Epigenetics, was published in the journal Translational Psychiatry. The study, “Transcriptomics identifies STAT3 as a key regulator of hippocampal gene expression and anhedonia during withdrawal from chronic alcohol exposure,” builds on her

Storytelling is one of the most effective ways to share our experiences and impart meaning onto our world. Through stories, we can connect with others in different levels, learn something new or feel inspired to explore new ideas. At the Institute of Translational Health Sciences (ITHS) we have an opportunity to do this by sharing our own stories of innovation, successes, research, new projects

Summary: Stakeholder engagement can play an important role in increasing public trust and the understanding of scientific research and its impact. Frameworks for stakeholder identification exist, but these frameworks may not apply well to basic science and early stage translational research. Methods: Four Clinical and Translational Science Award (CTSA) hubs led six focus groups and two semi

Educational Content

University Of Washington
University Of California San Francisco
Clinical mentoring is a vital component of a comprehensive clinical training program, helping to bridge the gap between new skills, knowledge, and attitudes obtained in the classroom, and effective application of these in the health care setting. This clinical mentoring toolkit is a comprehensive guide for developing, implementing, and evaluating clinical mentoring programs. This updated edition
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University Of Washington

University of Washington’s Institute of Translational Health Sciences is hosting Travis Kinder from the NCATS Intramural Research Program through the NIH Clinical and Translational Science Award (CTSA) Visiting Scholars Program on April 16 at 12pm PST. This program is designed to connect individuals with institutional KL2 awards from outside the UW with established UW faculty in their field as

UW ITHS Logo
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University Of Washington

The CTSA Center for Leading Innovation and Collaboration (CLIC) program has created the new NIH Clinical and Translational Science Award (CTSA) Visiting Scholars Program to help promote networking among KL2 Scholars. During the pandemic, KL2 Scholars are unable to visit other institutions or conferences to give presentations and network as they have in the past. This new program provides scholars

UW ITHS Logo
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University Of Washington
The CTSA Center for Leading Innovation and Collaboration (CLIC) program has created the new NIH Clinical and Translational Science Award (CTSA) Visiting Scholars Program to help promote networking among KL2 Scholars. During the pandemic, KL2 Scholars are unable to visit other institutions or conferences to give presentations and network as they have in the past. This new program provides scholars

Poster Sessions

Virginia Commonwealth University
University of Nebraska Medical Center
University Of Washington
University Of Alabama At Birmingham
University Of North Carolina Chapel Hill
Johns Hopkins University
Mayo Clinic
Oregon Health and Science University

Many clinical questions have arisen with the COVID-19 pandemic, from who is at greatest risk for COVID-19 infection to adverse outcomes if infected to how COVID-19 has impacted healthcare utilization patterns. To help answer these questions, and many more, the National COVID Cohort Collaborative (N3C) has integrated real-world clinical observations from across the nation into a harmonized database

University Of Washington
University of Tennessee

Since the first cases of COVID-19 arrived in the United States, various studies have reported that the SARS-CoV-2 virus is highly infectious and there has been a disproportionately greater negative impact upon communities already facing issues with racial disparities and challenges with social determinants of health (SDOH). Health systems, like UW Medicine, have provided SARS-CoV-2 testing to

Publications

Thresholds for post-rebound SHIV control after CCR5 gene-edited autologous hematopoietic cell transplantation

Autologous, CCR5 gene-edited hematopoietic stem and progenitor cell (HSPC) transplantation is a promising strategy for achieving HIV remission. However, only a fraction of HSPCs can be edited ex vivo to provide protection against infection. To project the thresholds of CCR5-edition necessary for HIV

CMV viral load kinetics as surrogate endpoints after allogeneic transplantation

BACKGROUNDViral load (VL) surrogate endpoints transformed development of HIV and hepatitis C therapeutics. Surrogate endpoints for CMV-related morbidity and mortality could advance development of antiviral treatments. Although observational data support using CMV VL as a trial endpoint, randomized

F-domain valency determines outcome of signaling through the angiopoietin pathway

Angiopoietin 1 and 2 (Ang1 and Ang2) modulate angiogenesis and vascular homeostasis through engagement of their very similar F-domain modules with the Tie2 receptor tyrosine kinase on endothelial cells. Despite this similarity in the underlying receptor binding interaction, the two angiopoietins

Research and Operational Tools

University Of Washington

In this time of unprecedented research need, the Institute of Translational Health Sciences is working relentlessly to provide research resources and help accelerate research that will help resolve the COVID-19 pandemic.

Title Authored Sort ascending Content type
UIC research identifies potential pathways to treating alcohol use disorder, depression June 29, 2021 Consortium News
CTSA Visiting Scholars Program Grand Rounds- Travis Kinder, PhD "Assay development and high throughput screening to identify potential therapeutics for myositis." March 05, 2021 Event
CTSA Visiting Scholars Program Grand Rounds- Heidi Munger Clary, MD, MPH "Anxiety & depression in epilepsy: Learning health system research to address care gaps” March 03, 2021 Event
CTSA Visiting Scholars Program- John McGinnis, "The lung microbiome after lung transplantation”. February 23, 2021 Event
Assessing the Impact of COVID-19 on Immunocompromised Persons: N3C ImmunoSuppressed/Compromised Clinical Domain Team October 29, 2020 Poster
Examining the dynamics in social determinants of health and COVID-19 patient cohort research October 26, 2020 Poster
A framework for studying machine learning methods in healthcare: The first EHR DREAM Challenge October 22, 2020 Poster
Scaling REDCap Resource Needs as a Result of the COVID-19 Pandemic October 22, 2020 Poster
Creating an Effective and Compliant Research Data Request Process October 22, 2020 Poster
Comparing Three Methods of Extracting COVID-19 Related Symptoms from EHR Data in a Large Healthcare System October 22, 2020 Poster
Extracting COVID-19 Diagnoses and Symptoms from Clinical Text: A New Annotated Corpus and Neural Event Extraction Framework October 20, 2020 Poster
Preserving the Scientific Integrity of Getting to COVID-19 Vaccines: From Clinical Trials to Public Allocation October 05, 2020 Event
ITHS Gene & Cell Therapy Lab Story: Exploring a Treatment for Ovarian Cancer September 01, 2020 Consortium News
Facilitating stakeholder engagement in early stage translational research July 10, 2020 Consortium News
A Multicenter, Adaptive, Randomized Blinded Controlled Trial of the Safety and Efficacy of Investigational Therapeutics for the Treatment of COVID-19 in Hospitalized Adults April 20, 2020 Covid Study
Institute of Translational Health Sciences COVID-19 Research Resources March 31, 2020 Research or Operational Tool
Clinical Mentoring Toolkit February 26, 2020 Educational Content
Collaborative Conversations: The Critical Need for Professional Workforce Development at Academic Medical Centers February 10, 2020 Event
The CTSA External Reviewer Exchange Consortium (CEREC): Engagement and Efficacy October 15, 2019 Consortium News
UNIVERSITY OF WASHINGTON February 05, 2019 CTSA Program Hub
Data and Safety Monitoring Board Training Manual Now Available June 01, 2018 Consortium News