Yale Center for Clinical Investigation

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Mission Statement

The YCCI has been to establish a home for the training of the next generation of clinical and translational scientists and to provide a robust infrastructure that promotes innovative and collaborative research directed at improving patient care. Our key goals are to:

Attract talented students and junior faculty members from the Schools of Medicine, Nursing, Public Health, and Engineering into clinical and translational research careers; imbue them with a spirit of discovery; train them in the use of state-of-the-art research tools; and give them the skills needed to function collaboratively as members of multidisciplinary research teams.
Accelerate the movement of disease-related discoveries into the clinic by providing research teams with pilot grants, access to state-of-the-art research cores, and robust administrative, regulatory, informatics, biostatistics, and subject recruitment support for T1-T4 research.
Strengthen the infrastructure that connects clinical research teams with practitioners, community health clinics, and community stakeholders throughout Connecticut, reaching out in particular to diverse populations including children, women, the elderly, and underserved minorities.
Work actively with other CTSA hubs to share research approaches, expertise, tools, data, and the integration of informatics systems and other key research functions.

At a Glance


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UL1 Award

KL2 Award

TL1 Award

Funded Years
2012 - 2021

Educational Content

Yale University

In this course you will engage in a series of challenges designed to increase your own happiness and build more productive habits. As preparation for these tasks, Professor Laurie Santos reveals misconceptions about happiness, annoying features of the mind that lead us to think the way we do, and the research that can help us change. You will ultimately be prepared to successfully incorporate a

Poster Sessions

Yale University

We sought to understand how U.S. residents responded to COVID-19 as it emerged, and the extent to which socioeconomic status impacted response. We found that highly resourced areas (low ADI) were concerned with stocks, social distancing, and national-level policies, while high ADI areas shared content with negative expression, prayers, and discussion of the CARES Act economic relief package


A little help from residual β cells has long-lasting clinical benefits

Following type 1 diabetes (T1D) diagnosis, declining C-peptide levels reflect deteriorating β cell function. However, the precise C-peptide levels that indicate protection from severe hypoglycemia remain unknown. In this issue of the JCI, Gubitosi-Klug et al. studied participants from the landmark

Pain and Symptoms after Mild Traumatic Brain Injury: Should Technology Play a Role in Self-Management?

Those with mild traumatic brain injury (mTBI) often experience pain and symptoms long after their initial injury. A gap in current knowledge is how persons would prefer to monitor and manage these symptoms following mTBI. The purpose of this study was to explore self-management strategies to inform

Parasite burden and red blood cell exchange transfusion for babesiosis

The association between parasite burden and end-organ dysfunction in subjects with Babesia microti infection has not been extensively studied, nor has the optimal role of red blood cell exchange (RCE) transfusion in babesiosis treatment. This retrospective chart review evaluates the associations

Funding opportunity 2020

The National Institutes of Health (NIH) awarded a research team at George Washington (GW), Yale, and Duke Universities $7.8 million to establish a rare disease network for Myasthenia Gravis.