Balancing Damage and Protection, Neutrophils May Lead to Cell Aging, Mayo study says

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Mayo Clinic
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Medical illustration of senescent cells, greenish, among normal cells.

The action of an immune cell called a neutrophil may contribute to tissue aging, according to a new study. As neutrophils do their job, they may damage chromosomes in nearby cells which, over time, may lead to cellular senescence. This new concept may help clarify cell aging. It also suggests targeting neutrophils might be helpful in treatment of age-related disease.

This research was funded, in part, by the Mayo Clinic Center for Clinical and Translational Science.

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