Mayo Clinic

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    Mayo Clinic Center for Clinical and Translational Science

    Mayo Clinic Center for Clinical and Translational Science (CCaTS) connects researchers to the people, information and resources they need to keep medical science moving forward. CCaTS is a central hub for institutional advancement of research and education at Mayo Clinic. The center provides tools and expert consultation to support every aspect of medical research, including basic discovery science, clinical and community-engaged research, and late-stage application and commercialization.
  • Mobile apps are popular tools for people looking to improve their health, but are they effective? They can be if the app is culturally tailored to the needs of its users. In a study published on Monday, July 18, in Circulation, Mayo Clinic researchers evaluated the effectiveness of a culturally relevant mobile app designed to improve heart health among African Americans in faith communities. The

  • When scientific advances burst into the news, such as a new medication to treat COVID-19 or a new concept like CRISPR for gene editing, people get a glimpse of how a scientific idea becomes a treatment or a tool. But what's the full story? Where did that idea come from? What happens in the research lab before clinical trials begin? How is scientific discovery transformed into a potential therapy

  • Somali and Latino immigrants lost weight when they worked together in culturally specific groups and received coaching by someone from their community. The Mayo Clinic’s pilot study was such a success it’s being replicated on a larger scale.

  • Editor's note: Mayo Clinic advances health equity by collaborating with communities in research that addresses their health concerns and aims to reduce health disparities. This article is the third in the Raising Up Community Voices in Research series. This series is written by community members who collaborate with Mayo Clinic on community-driven medical research. In this essay, Eula Saxon Dean

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    Mayo Clinic

    The CTSA Visiting Scholar program consists of giving the virtual CTSA Grand Rounds lecture, which is open to the entire CTSA Consortium, and virtual meetings between KL2 Scholars and faculty at the host institution and their KL2 peers. There are two main goals of this program. The first is to offer the opportunity to serve as a visiting professor and help make connections with faculty that will

  • During the COVID-19 pandemic, many people's lives were disrupted, and isolation increased. And with that isolation came weight gain. The Centers for Disease Control and Prevention says children and adults have gained weight during the pandemic, stressing that obesity worsens COVID-19 outcomes. However, a recent Mayo Clinic community-based pilot study suggests that weight gain can be prevented and

  • Public health experts report that members of immigrant and refugee communities continue to be disproportionately affected by the COVID-19 pandemic, with higher rates of infection and death. Health disparities can be associated with job type, immigration status and English proficiency. A team of Mayo Clinic medical experts and community leaders collaborated to find ways to reduce health disparities

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    Mayo Clinic

    The CTSA Visiting Scholar program consists of giving the virtual CTSA Grand Rounds lecture, which is open to the entire CTSA Consortium, and virtual meetings between KL2 Scholars and faculty at the host institution and their KL2 peers. There are two main goals of this program. The first is to offer the opportunity to serve as a visiting professor and help make connections with faculty that will

  • Twelve teams from Mayo Clinic and across Minnesota cast their reels in "Walleye Tank: Ice Fishing Edition" competition in December 2021. Over 200 people gathered virtually to watch as teams in three divisions — Junior Angler, Midlevel Reeler and Professionals — pitched their biomedical innovation ideas before a panel of expert judges. Inspired by TV's "Shark Tank," Walleye Tank is a competition

  • A commentary by researchers from Mayo Clinic and the University of Southern California suggests that agencies funding biomedical research must strive for diversity, equity and inclusion in research decisions, and that these agencies will only be successful if they address bias in the research funding process. The commentary is published in Nature Medicine. "The lack of diversity in science and
  • Dasatinib, a drug that often is used to treat certain types of leukemia, may have antidiabetic effects comparable to medications used to treat diabetes, and with more research may become a novel therapy for diabetic patients, according to new research published in Mayo Clinic Proceedings. The study was supported by the National Center for Advancing Translational Sciences; the Robert and Arlene

  • When she was an orthopedics resident in her native Germany, Christine Mehner, M.D., Ph.D., noted that the nails used to set fractures didn’t provide the best possible outcomes to stabilize fractured long bones, such as the tibia, femur and humerus. In standard surgery to fix a tibia fracture, for example, a surgeon’s experience determines adequate positioning of the patient’s leg and foot to

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    Objectives: To assess the impact of the COVID-19 pandemic on clinical research and the use of electronic approaches to mitigate this impact. Methods: We compared the utilization of electronic consenting, remote visits, and remote monitoring by study monitors in all research studies conducted at Mayo Clinic sites (Arizona, Florida, and Minnesota) before and during the COVID-19 pandemic (ie, between

  • A growing body of research points to the profound effects of structural and interpersonal racism on health equity. This is particularly true when it comes to cardiovascular disease and related conditions, such as high blood pressure and obesity. In Minnesota, people of color experience some of the worst health disparities in the U.S. The Center for Chronic Disease Reduction and Equity Promotion

  • October is Liver Cancer Awareness Month. Viral hepatitis is the leading cause of liver cancer worldwide. There are established treatments and vaccines for prevention. Unfortunately, barriers prevent the people who most need this care from receiving it. Meet two Mayo Clinic health equity researchers-- Essa Mohamed, Ph.D., and his mentor Lewis Roberts, M.B., Ch.B., Ph.D., --who have made it their

  • A Rochester company that developed a device that reduces the size of eye droplets by 60% won the grand prize of the Minnesota Cup on Monday night, beating nearly 2,000 other companies that entered what has become the largest statewide competition for startups in Minnesota. Led by a Mayo Clinic medical student, Nanodropper Inc. won the $50,000 grand prize, in addition to $25,000 for winning its

  • The microscope hovers over a small dish. It's attached to a laptop, so students don't need to press their faces against a microscope eyepiece. On the screen is a zebrafish egg. On hand to answer questions are scientists. The questions, however, are a little different from the ones they get from colleagues. "One of the questions I got was how does gravity work, and I was like, 'Oh that's a great

  • Beriberi, which affects metabolic, neurologic, cardiovascular, respiratory, gastrointestinal and musculoskeletal systems, was largely eradicated in developed countries more than 70 years ago. Over the past 20 years, Philip Fischer, M.D., has been engaged in health disparities research to find ways to do the same in countries where the disease persists today.

  • Mayo Clinic researchers work with community leaders who help us understand the best way to address community health concerns and reduce health disparities. Clarence Jones is a community leader who works with Dr. LaPrincess Brewer and the Fostering African American Improvement In Total Health (FAITH!) project. Clarence recently authored an article for Mayo's Advancing the Science blog sharing his

  • No champion race car driver can win without a dedicated pit crew. The same is true in medical research. Thanks to their “pit crew” Mayo Clinic researchers were able to repurpose an experimental therapy, called lenzilumab, for patients with COVID-19 pneumonia, and from there into a phase three clinical trial — all in about one year. "I think we’ve accomplished in this year what normally would take

  • “It was surreal, it seemed like this day would never come at times,” says Jacqueline Zayas, of the many hours spent in the lab and classroom working toward her M.D., and Ph.D. For as long as she could remember, Dr. Zayas, who hails from Miami, Fla., says she would tell her family that she wanted to become a doctor. The M.D. - Ph.D. program, offered by the Mayo Clinic Center for Clinical and

  • Clinical trials help researchers discover and apply critical advances in patient care. Clinical trials follow rigorous scientific processes that usually take many years to complete. However, during the COVID-19 pandemic, people have been able to see and experience clinical trials operating on fast-forward. And a lot of people are wondering, "How do clinical trials work?" In this Q&A, the Mayo

  • Children are underrepresented and understudied in clinical trials, limiting the number of children-focused research studies and the overall advancement of pediatric medicine. To address this, Mayo Clinic researchers established a first-of-its-kind Pediatric Advisory Board to engage youth as partners in research and enhance pediatric research participation. A description of the board and results of

  • Community engagement is the bridge that connects researchers and local communities; however, face-to-face engagement is often limited in reach and scale — especially during a pandemic. In a recently published paper, researchers from Mayo Clinic and the University of Minnesota evaluated the feasibility of a virtual statewide Facebook community platform to enhance public trust and engagement with

  • The action of an immune cell called a neutrophil may contribute to tissue aging, according to a new study. As neutrophils do their job, they may damage chromosomes in nearby cells which, over time, may lead to cellular senescence. This new concept may help clarify cell aging. It also suggests targeting neutrophils might be helpful in treatment of age-related disease. This research was funded, in

  • Monica Albertie leads a small but mighty team of four research operations and program managers at Mayo Clinic, and they have a very important charge: Keep Mayo health equity research running full steam at all times. The team, part of the Center for Health Equity and Community Engagement Research, supports dozens of research teams across Mayo Clinic. The team helps researchers write protocols and

  • U.S. public health officials report that the COVID-19 pandemic has disproportionately affected communities that have been medically underserved, leading to higher infection and mortality rates. A Mayo Clinic study recently published in the American Journal of Public Health says easy access to rapid testing is needed to combat disparities, and a community-driven and culturally tailored strategy is

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    Mayo Clinic

    Sjӧgren's syndrome (SS), the second most common rheumatic disease contributing nine times the cost of a healthy person, has hallmark features of oral and ocular dryness due to salivary and lacrimal gland inflammation. Minor salivary glands, central to the pathogenesis and diagnosis of SS, contain mesenchymal stromal cells (MSCs). In other conditions MSCs are responsible for tissue repair and

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    Mayo Clinic

    Almost all cardiovascular variables that have been assessed at different times of day and night in humans have been found to have a day/night pattern, including blood pressure heart rate, and vascular endothelial function. These patterns result from the summation of predictable circadian effects with variable behavioral (e.g. sleep, exercise, and meal intake) and environmental (e.g. temperature)