Mayo Clinic

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    Mayo Clinic Center for Clinical and Translational Science

    Mayo Clinic Center for Clinical and Translational Science (CCaTS) connects researchers to the people, information and resources they need to keep medical science moving forward. CCaTS is a central hub for institutional advancement of research and education at Mayo Clinic. The center provides tools and expert consultation to support every aspect of medical research, including basic discovery science, clinical and community-engaged research, and late-stage application and commercialization.
  • A commentary by researchers from Mayo Clinic and the University of Southern California suggests that agencies funding biomedical research must strive for diversity, equity and inclusion in research decisions, and that these agencies will only be successful if they address bias in the research funding process. The commentary is published in Nature Medicine. "The lack of diversity in science and
  • Dasatinib, a drug that often is used to treat certain types of leukemia, may have antidiabetic effects comparable to medications used to treat diabetes, and with more research may become a novel therapy for diabetic patients, according to new research published in Mayo Clinic Proceedings. The study was supported by the National Center for Advancing Translational Sciences; the Robert and Arlene

  • When she was an orthopedics resident in her native Germany, Christine Mehner, M.D., Ph.D., noted that the nails used to set fractures didn’t provide the best possible outcomes to stabilize fractured long bones, such as the tibia, femur and humerus. In standard surgery to fix a tibia fracture, for example, a surgeon’s experience determines adequate positioning of the patient’s leg and foot to

  • Mayo Clinic

    Objectives: To assess the impact of the COVID-19 pandemic on clinical research and the use of electronic approaches to mitigate this impact. Methods: We compared the utilization of electronic consenting, remote visits, and remote monitoring by study monitors in all research studies conducted at Mayo Clinic sites (Arizona, Florida, and Minnesota) before and during the COVID-19 pandemic (ie, between

  • A growing body of research points to the profound effects of structural and interpersonal racism on health equity. This is particularly true when it comes to cardiovascular disease and related conditions, such as high blood pressure and obesity. In Minnesota, people of color experience some of the worst health disparities in the U.S. The Center for Chronic Disease Reduction and Equity Promotion

  • October is Liver Cancer Awareness Month. Viral hepatitis is the leading cause of liver cancer worldwide. There are established treatments and vaccines for prevention. Unfortunately, barriers prevent the people who most need this care from receiving it. Meet two Mayo Clinic health equity researchers-- Essa Mohamed, Ph.D., and his mentor Lewis Roberts, M.B., Ch.B., Ph.D., --who have made it their

  • A Rochester company that developed a device that reduces the size of eye droplets by 60% won the grand prize of the Minnesota Cup on Monday night, beating nearly 2,000 other companies that entered what has become the largest statewide competition for startups in Minnesota. Led by a Mayo Clinic medical student, Nanodropper Inc. won the $50,000 grand prize, in addition to $25,000 for winning its

  • The microscope hovers over a small dish. It's attached to a laptop, so students don't need to press their faces against a microscope eyepiece. On the screen is a zebrafish egg. On hand to answer questions are scientists. The questions, however, are a little different from the ones they get from colleagues. "One of the questions I got was how does gravity work, and I was like, 'Oh that's a great

  • Beriberi, which affects metabolic, neurologic, cardiovascular, respiratory, gastrointestinal and musculoskeletal systems, was largely eradicated in developed countries more than 70 years ago. Over the past 20 years, Philip Fischer, M.D., has been engaged in health disparities research to find ways to do the same in countries where the disease persists today.

  • Mayo Clinic researchers work with community leaders who help us understand the best way to address community health concerns and reduce health disparities. Clarence Jones is a community leader who works with Dr. LaPrincess Brewer and the Fostering African American Improvement In Total Health (FAITH!) project. Clarence recently authored an article for Mayo's Advancing the Science blog sharing his

  • No champion race car driver can win without a dedicated pit crew. The same is true in medical research. Thanks to their “pit crew” Mayo Clinic researchers were able to repurpose an experimental therapy, called lenzilumab, for patients with COVID-19 pneumonia, and from there into a phase three clinical trial — all in about one year. "I think we’ve accomplished in this year what normally would take

  • “It was surreal, it seemed like this day would never come at times,” says Jacqueline Zayas, of the many hours spent in the lab and classroom working toward her M.D., and Ph.D. For as long as she could remember, Dr. Zayas, who hails from Miami, Fla., says she would tell her family that she wanted to become a doctor. The M.D. - Ph.D. program, offered by the Mayo Clinic Center for Clinical and

  • Clinical trials help researchers discover and apply critical advances in patient care. Clinical trials follow rigorous scientific processes that usually take many years to complete. However, during the COVID-19 pandemic, people have been able to see and experience clinical trials operating on fast-forward. And a lot of people are wondering, "How do clinical trials work?" In this Q&A, the Mayo

  • Children are underrepresented and understudied in clinical trials, limiting the number of children-focused research studies and the overall advancement of pediatric medicine. To address this, Mayo Clinic researchers established a first-of-its-kind Pediatric Advisory Board to engage youth as partners in research and enhance pediatric research participation. A description of the board and results of

  • Community engagement is the bridge that connects researchers and local communities; however, face-to-face engagement is often limited in reach and scale — especially during a pandemic. In a recently published paper, researchers from Mayo Clinic and the University of Minnesota evaluated the feasibility of a virtual statewide Facebook community platform to enhance public trust and engagement with

  • The action of an immune cell called a neutrophil may contribute to tissue aging, according to a new study. As neutrophils do their job, they may damage chromosomes in nearby cells which, over time, may lead to cellular senescence. This new concept may help clarify cell aging. It also suggests targeting neutrophils might be helpful in treatment of age-related disease. This research was funded, in

  • Monica Albertie leads a small but mighty team of four research operations and program managers at Mayo Clinic, and they have a very important charge: Keep Mayo health equity research running full steam at all times. The team, part of the Center for Health Equity and Community Engagement Research, supports dozens of research teams across Mayo Clinic. The team helps researchers write protocols and

  • U.S. public health officials report that the COVID-19 pandemic has disproportionately affected communities that have been medically underserved, leading to higher infection and mortality rates. A Mayo Clinic study recently published in the American Journal of Public Health says easy access to rapid testing is needed to combat disparities, and a community-driven and culturally tailored strategy is

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    Mayo Clinic

    Sjӧgren's syndrome (SS), the second most common rheumatic disease contributing nine times the cost of a healthy person, has hallmark features of oral and ocular dryness due to salivary and lacrimal gland inflammation. Minor salivary glands, central to the pathogenesis and diagnosis of SS, contain mesenchymal stromal cells (MSCs). In other conditions MSCs are responsible for tissue repair and

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    Mayo Clinic

    Almost all cardiovascular variables that have been assessed at different times of day and night in humans have been found to have a day/night pattern, including blood pressure heart rate, and vascular endothelial function. These patterns result from the summation of predictable circadian effects with variable behavioral (e.g. sleep, exercise, and meal intake) and environmental (e.g. temperature)

  • Esophageal cancer is relatively rare, making up only about 1% of cancer cases diagnosed each year in the U.S. Mayo Clinic researchers have found that esophageal adenocarcinoma, a type of esophageal cancer, has been rising in incidence over the past 40 years, particularly among people under 50. More concerning is that these younger patients tend to be diagnosed when the cancer is already at a more

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    Fundamentals of Clinical and Translational Science (FunCaTS) is a combination of 13 online modules strategically packaged together to enable medical professionals and allied health staff to expand their knowledge of the components of clinical and translational research. These components provide the fundamental knowledge to promote understanding of the process of bringing discoveries to the bedside

  • Mayo Clinic

    Are you ready to take a deeper dive into the world of clinical and translational science? Essentials of Clinical and Translational Science (ECaTS) provides medical professionals with foundational knowledge of research terminology, research methods and processes, clinical epidemiology, and biomedical statistics. Upon completion, learners understand basic terminology and methodological concepts in

  • Black churches have long been strongholds for sharing trusted health information with their communities, and never has that role been more important than during the COVID-19 pandemic. A new paper details how Mayo researchers are working with Black churches in MN to address COVID-19 health disparities.

  • Vasculitis Clinical Research Consortium

    Vasculitis refers to a group of rare diseases that involve inflammation of blood vessels, which disrupts blood flow and often causes damage to the body’s organs. The cause of most forms of vasculitis remains unknown, and treatments involve the use of strong medications that can have serious side effects. The Vasculitis Clinical Research Consortium (VCRC) is an international, multicenter clinical

  • North American Mitochondrial Disease Consortium (NAMDC)

    Mitochondrial diseases affect approximately 1 in every 5,000 people. These diseases can cause muscle weakness, difficulty thinking, seizures, hearing and vision loss, digestive problems, learning disabilities, and organ failure. The North American Mitochondrial Disease Consortium (NAMDC) is a network of clinicians and researchers at 17 different clinical sites working to better understand

  • Nephrotic Syndrome Rare Disease Clinical Research Network III (NEPTUNE)

    Focal and Segmental Glomerulosclerosis, Minimal Change Disease, and Membranous Nephropathy, presenting as Nephrotic Syndrome (NS), are a group of rare renal diseases that may cause serious complications and end-stage kidney disease, generating significant individual, societal and economic burdens. The Nephrotic Syndrome Study Network (NEPTUNE) brings together physician scientists at 26 sites in

  • Frontiers in Congenital Disorders of Glycosylation (FCDGC)

    Congenital disorders of glycosylation (CDG) consist of more than 130 different inborn errors of metabolism at an estimated overall incidence of greater than 1 in 100,000. While these disorders were first genetically defined in the 1990s, there is no data available on their natural history, no comprehensive patient registry, no reliable screening tests for many types, and large gaps in clinical

  • Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR)

    Eosinophilic esophagitis, eosinophilic gastritis, eosinophilic gastroenteritis, and eosinophilic colitis are disorders in which a type of immune cell (called eosinophils) builds up in the digestive tract, causing gastrointestinal tissue damage. These disorders are painful, lifelong, and make it hard or impossible for people to eat many or all foods. The Consortium of Eosinophilic Gastrointestinal