University Of Washington
June 29, 2021Amy Lasek, a former UIC Center for Clinical and Translational Science pilot grant awardee (2018-2020) and researcher at UIC’s Center for Alcohol Research in Epigenetics, was published in the journal Translational Psychiatry. The study, “Transcriptomics identifies STAT3 as a key regulator of hippocampal gene expression and anhedonia during withdrawal from chronic alcohol exposure,” builds on her
-University Of WashingtonUniversity of Washington’s Institute of Translational Health Sciences is hosting Travis Kinder from the NCATS Intramural Research Program through the NIH Clinical and Translational Science Award (CTSA) Visiting Scholars Program on April 16 at 12pm PST. This program is designed to connect individuals with institutional KL2 awards from outside the UW with established UW faculty in their field as
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-University Of Washington
The CTSA Center for Leading Innovation and Collaboration (CLIC) program has created the new NIH Clinical and Translational Science Award (CTSA) Visiting Scholars Program to help promote networking among KL2 Scholars. During the pandemic, KL2 Scholars are unable to visit other institutions or conferences to give presentations and network as they have in the past. This new program provides scholars
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-University Of WashingtonThe CTSA Center for Leading Innovation and Collaboration (CLIC) program has created the new NIH Clinical and Translational Science Award (CTSA) Visiting Scholars Program to help promote networking among KL2 Scholars. During the pandemic, KL2 Scholars are unable to visit other institutions or conferences to give presentations and network as they have in the past. This new program provides scholars
Focal and Segmental Glomerulosclerosis, Minimal Change Disease, and Membranous Nephropathy, presenting as Nephrotic Syndrome (NS), are a group of rare renal diseases that may cause serious complications and end-stage kidney disease, generating significant individual, societal and economic burdens. The Nephrotic Syndrome Study Network (NEPTUNE) brings together physician scientists at 26 sites in
Lysosomal disorders (LD) are a group of approximately 70 inherited conditions resulting from defects in lysosomal function, usually the deficiency of a single enzyme required for the metabolism of lipids, glycoproteins, or mucopolysaccharides. Collectively, LD are not especially rare, and estimates suggest that roughly 1 in 5,000 newborns will be affected with one identified LD. However, each
The Genetic Disorders of Mucociliary Clearance Consortium (GDMCC) focuses on several inherited and acquired disorders that cause thickened, infected secretions to accumulate in the upper and lower airways. Its work is conducted at eight clinical research sites across the United States and Canada. During the past 15 years, the consortium has made numerous advances that profoundly changed clinical
Virginia Commonwealth UniversityUniversity of Nebraska Medical CenterUniversity Of WashingtonUniversity Of Alabama At BirminghamUniversity Of North Carolina Chapel HillJohns Hopkins UniversityMayo ClinicOregon Health and Science UniversityMany clinical questions have arisen with the COVID-19 pandemic, from who is at greatest risk for COVID-19 infection to adverse outcomes if infected to how COVID-19 has impacted healthcare utilization patterns. To help answer these questions, and many more, the National COVID Cohort Collaborative (N3C) has integrated real-world clinical observations from across the nation into a harmonized database
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University Of WashingtonUniversity of Tennessee
Since the first cases of COVID-19 arrived in the United States, various studies have reported that the SARS-CoV-2 virus is highly infectious and there has been a disproportionately greater negative impact upon communities already facing issues with racial disparities and challenges with social determinants of health (SDOH). Health systems, like UW Medicine, have provided SARS-CoV-2 testing to
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University Of Washington
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University Of Washington
The Institute of Translational Health Sciences (ITHS) at the University of Washington (UW) maintains a REDCap instance that has seen nearly exponential growth since its inception in 2009, making it one of the largest globally. We've been successful in operating that instance with a modest resource allocation and computational infrastructure. Before the pandemic, we had scaled to nearly 20k
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University Of Washington
Understanding the complexities of requesting research data within a large academic health system can be a challenge for investigators. The University of Washington (UW) is working to provide the research community with avenues for requesting data that are both simple to understand and execute. From self-service tools both in and outside of the Electronic Health Record (EHR), to a well-defined
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University Of Washington
Introduction The COVID-19 pandemic has claimed over 220,000 lives in the United States. A promising resource for discovery in COVID-19’s symptom progress is data documented in electronic health record (EHR) systems as part of clinical care. Such data are stored in disparate locations within the EHR, requiring multiple extraction methods. Methods Symptoms were extracted from EHR data for all
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University Of Washington
Coronavirus disease 2019 (COVID-19) is a global pandemic. Although much has been learned about the novel coronavirus since its emergence, there are many open questions related to tracking its spread, describing symptomology, predicting the severity of infection, and forecasting healthcare utilization. Free-text clinical notes contain critical information for resolving these questions. Data-driven
-Johns Hopkins UniversityThere are now more than 33 million confirmed COVID-19 cases worldwide and the death toll of the global pandemic is nearing 1 million. The United States remains the most affected country, with more than 7 million diagnosed COVID-19 infections and upwards of 200,000 deaths to date. The pandemic has also had enormous social and economic impacts globally, and continues to challenge families
September 01, 2020Storytelling is one of the most effective ways to share our experiences and impart meaning onto our world. Through stories, we can connect with others in different levels, learn something new or feel inspired to explore new ideas. At the Institute of Translational Health Sciences (ITHS) we have an opportunity to do this by sharing our own stories of innovation, successes, research, new projects
July 10, 2020Summary: Stakeholder engagement can play an important role in increasing public trust and the understanding of scientific research and its impact. Frameworks for stakeholder identification exist, but these frameworks may not apply well to basic science and early stage translational research. Methods: Four Clinical and Translational Science Award (CTSA) hubs led six focus groups and two semi
The Strategies to Innovate EmeRgENcy Care Clinical Trials Network (SIREN) is a clinical trials network funded by the National Institute for Neurological Disorders and Stroke (NINDS), the National Heart Lung and Blood Institute (NHLBI) and the National Center for Advancing Translational Science (NCATS). The goal of the SIREN Network is to improve the outcomes of patients with neurologic, cardiac
University Of WashingtonIn this time of unprecedented research need, the Institute of Translational Health Sciences is working relentlessly to provide research resources and help accelerate research that will help resolve the COVID-19 pandemic.
A leading cause of illness and death worldwide is Chronic Obstructive Pulmonary Disease (COPD), a group of lung diseases that make it difficult to breath. The COPD Outcomes-based Network for Clinical Effectiveness & Research Translation (CONCERT) is a consortium of six Clinical Centers and a Data Coordinating Center whose mission is to pool their expertise to ease the suffering caused by COPD. The
University Of WashingtonUniversity Of California San FranciscoClinical mentoring is a vital component of a comprehensive clinical training program, helping to bridge the gap between new skills, knowledge, and attitudes obtained in the classroom, and effective application of these in the health care setting. This clinical mentoring toolkit is a comprehensive guide for developing, implementing, and evaluating clinical mentoring programs. This updated edition
-University Of WashingtonThe purpose of this meeting is to use an Un-Meeting format to enhance focused discussions on topics related to workforce development for clinical research professionals (CRPs) working in academic medical centers (AMCs), especially those that are working on federally-funded clinical research. Originally planned as a face-to-face half-day event, we are now converting these collaborative
October 15, 2019What is CEREC? CEREC was established in 2016 to provide an outlet for obtaining external reviews for CTSA-funded pilot research and to minimize the likelihood of bias and conflicts of interest. CEREC also offers a larger pool of expertise from which to draw precisely matched reviews for scientific lines of inquiry that may not be well represented within the institution receiving the proposal. This- Image
UW Medicine
The Institute of Translational Health Sciences is dedicated to speeding science to clinic practice for the benefit of patients and communities throughout Washington, Wyoming, Alaska, Montana, Idaho (WWAMI), and beyond. ITHS promotes this translation of scientific discovery to practice by fostering innovative research, cultivating multi-disciplinary research partnerships, and ensuring a pipeline of next generation researchers through robust educational and career development programs. In the past, individual groups looked at health issues only from their perspective. We now realize that partnerships between scientists, clinicians, and communities are needed to tackle complex health issues. The ITHS is a partnership between the University of Washington, Fred Hutchinson Cancer Research Center, and Seattle Children’s. We also collaborate with regional institutions, providers, and community organizations across the five-state WWAMI region.</p>
June 01, 2018The CTSA Collaborative Data and Safety Monitoring Board (DSMB) Workgroup identified a need to provide guidance, training and resources in DSMB practices for investigator-initiated research studies. To promote clinical and translational research, the CTSA Collaborative DSMB Workgroup, supported by NCATS, has produced an online DSMB Training Manual with a focus on investigator-initiated studies
