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Developing new therapies and getting them to patients is long and difficult. During public health emergencies, such as the Covid-19 Pandemic, science must move faster than ever. That is where translational science comes in. Translational science is focused on streamlining the process of moving (“translating”) lab findings into medical practice and treatments to improve health and well-being.
NCATS is supporting research activities spanning the translational science spectrum to address the novel coronavirus 2019 (SARS-CoV-2) and the disease it causes (COVID-19). To accelerate translational research, NCATS has developed research tools, technologies, expertise and collaborative networks that can quickly pivot to address urgent public health issues.
The N3Connect Bulletin aims to inform, connect, and engage members of the N3C community. The bulletin includes updates on community events, news, important announcements, and opportunities for involvement, as well as stories and profiles about N3C community members and their achievements. To join the N3Connect Bulletin mailing list, please visit https://bit.ly/JoinN3Connect
Towards Examining the Impact of COVID-19 on Oral Healthcare with Ye Lin and Chen Liang: People affected by COVID-19 may be at elevated risk for oral conditions whereas the causes are not clear. The Oral Health Domain Team strives to understand the impact of COVID-19 and Long COVID on the clinical progression, outcomes, and treatment optimization for dental patients. Our prioritized research will
Temporal Trends in Rural-Urban COVID-19 Therapies and Outcomes from Alpha to Omicron with Jerrod Anzalone: After an initial urban wave, the COVID-19 pandemic has disproportionately impacted rural communities. The N3C Rural Health Domain Team (https://covid.cd2h.org/rural-health) will present recent work examining temporal trends in rural-urban differences in frontline COVID-19 therapies and
The N3Connect Bulletin aims to inform, connect, and engage members of the N3C community. The bulletin includes updates on community events, news, important announcements, and opportunities for involvement, as well as stories and profiles about N3C community members and their achievements. To join the N3Connect Bulletin mailing list, please visit https://bit.ly/JoinN3Connect
Speaker: Elizabeth C (Lizzy) Oelsner, MD, MPH Dr. Oelsner is Herbert Irving Associate Professor in the Division of General Internal Medicine at Columbia University where she leads the NHLBI-supported Collaborative Cohort of Cohorts for COVID-19 Research (C4R; https://c4r-nih.org/), providing national leadership of a unique resource that brings together 14 longitudinal cohort studies that have been
A University of Arkansas for Medical Sciences (UAMS) research team’s article on COVID-19 vaccine hesitancy has been recognized by the publisher of Clinical and Translational Science for having its top-cited article in 2022 and the most downloaded paper since its publication in 2021. The article, “COVID-19 Vaccine Hesitancy: Race/Ethnicity, Trust and Fear,” resulted from a study conducted by
The findings that appear in Lancet Infectious Diseases are from one of the first studies to examine the effectiveness of nirmatrelvir-ritonavir (Paxlovid) in non-hospitalized patients during an Omicron period of the COVID-19 pandemic that includes BA.4 and BA.5 subvariants. Though many Coloradans are proceeding as though the COVID-19 pandemic is over, the virus continues to circulate, evolve and
Dear Colleagues, Please join us for the second of the 2023 Voices in Clinical and Translational Science seminar series presented by iTHRIV, Tuesday June 20, 2023 at Noon. The Voices in Clinical & Translational Science Seminar series serves as a platform to lift underrepresented voices in research across the iTHRIV partnership with a focus on promoting dialogue and encouraging team science. This
Malnutrition significantly increased the risk of mortality and adverse hospital events in patients hospitalized with COVID-19. In the United States, current estimates suggest that 20-50% of hospitalized patients have malnutrition. Malnutrition is a condition that develops when the body lacks sufficient vitamins, minerals and other nutrients needed to maintain healthy tissues and organ function. In
While much effort has gone into building predictive models of the COVID-19 pandemic, some have argued that early exponential growth combined with the stochastic nature of epidemics make the long-term prediction of contagion trajectories impossible. We conduct two complementary studies to assess model features supporting better long-term predictions. First, we leverage the diverse models
Excess cognitive dysfunction has been identified in older adult survivors of COVID-19, compared to other respiratory infections. SARS-CoV-2 may thus adversely impact the brain beyond what the cases of acute stroke, etc. suggest. Unrecognized brain effects of SARS-CoV-2 infection may impact current brain functioning and presage future neurodegeneration and overt neurologic dysfunction. However
Melissa Haendel, PhD, professor in the Department of Biochemistry and Molecular Genetics at the University of Colorado School of Medicine, and her team of data scientists have been working at a lightning-fast pace for two years, unlocking some of the mysteries of long COVID. Not only have they been instrumental in the development of the largest national, publicly available HIPAA-limited dataset in
APPLICATIONS DUE January 8th The global COVID-19 pandemic over the past two years has upset our lives in ways unimaginable before we took to wearing masks, isolating at home, and avoiding contact with family, friends, and colleagues. We are only now, just contending with the secondary effects of COVID exposures – so-called ‘long-haul COVID’ – but also the effects of deferred regular health check
Session recordings are now available from the DC CTSA Consortium's 2022 DC CTSA Spring Regulatory Update & Hot Topics in Clinical and Translational Research. DAY 1 - LASTING IMPACTS OF THE COVID-19 PANDEMIC (APRIL 28, 2022) - Keynote Address - Transcriptome profiling of human blood as a platform for diagnostic biomarker development: Measure broadly, listen carefully - Panel 1: Long-term COVID-19
Racial health disparities impact Coronavirus (COVID-19) infection and fatality rates. Hospitalization rates due to the pandemic among African Americans/Latinx/Hispanics in Georgia have been among the highest in the nation. Sociopolitical determinants, also termed Social Vulnerability (SV), have been identified as central among factors helping to explain the root causes associated with the
CLIC has had the honor of serving the CTSA Consortium as your Coordinating Center for the past 5+ years as we transformed the Consortium together. With Consortium members, CLIC launched innovative team science activities – non-traditional Un-meetings and cross-hub, cross-translational level Synergy Papers that have become part of the fabric of the CTSA Program. All hubs participated in one or more
Re-examining Our Approach to Research: Translational Science Lessons from the Pandemic The COVID-19 pandemic laid bare the urgent need to employ research methodologies better suited to more effectively, efficiently and equitably move therapeutics, vaccines and other interventions from bench to bedside to community. Reflecting on lessons learned, this conference will focus on successes and