COVID-19
Developing new therapies and getting them to patients is long and difficult. During public health emergencies, such as the Covid-19 Pandemic, science must move faster than ever. That is where translational science comes in. Translational science is focused on streamlining the process of moving (“translating”) lab findings into medical practice and treatments to improve health and well-being.
NCATS is supporting research activities spanning the translational science spectrum to address the novel coronavirus 2019 (SARS-CoV-2) and the disease it causes (COVID-19). To accelerate translational research, NCATS has developed research tools, technologies, expertise and collaborative networks that can quickly pivot to address urgent public health issues.
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Columbia University
The mission of the Irving Institute for Clinical and Translational Research is to advance discoveries, knowledge, and innovation to improve human health across the lifespan for diverse populations in upper Manhattan and around the world. By mobilizing and connecting Columbia University’s researchers, we aim to create a seamless integration of community and academic partnerships. Our commitment to train a multi-faceted workforce, provide vital resources to researchers, and improve the efficiency of research processes, promotes the collaborative team science framework needed to translate research discoveries into effective interventions that address current and future health concerns.
We provide over 70 different services and programs focused on education and training, seed funding, bioinformatics, biostatistics, clinical research, lifespan research and special populations, regulatory knowledge and bioethics, an off-site community facility and health informatics websites. 
September 16, 2022As we head into our third fall of the COVID pandemic, nearly one-third of the U.S. population is still not fully vaccinated, likely due in part to vaccine hesitancy. An Arts and Medicine article recently published in JAMA describes a UR CTSI-supported program that turned to improv theater for help addressing vaccine hesitancy. The program, called the Theater for Vaccine Hesitancy, combined improv
August 19, 2022CTSI KL2 scholar Carolyn Bramante, MD, MPH, led the nation’s first study on whether metformin, fluvoxamine, and ivermectin, or their combinations could serve as possible treatments to prevent ER visits or hospitalization, as well as Long-COVID. Yesterday, the New England Journal of Medicine published the results of the clinical trial. “Our trial suggests that metformin may reduce the likelihood of
- Journal of Clinical and Translational Science
Rapid development and deployment of diagnostic testing for COVID-19 have been a key component of the public health response to the pandemic. Out of necessity, academic and other clinical laboratories developed laboratory testing innovations for COVID-19 to meet clinical testing demands.
- Journal of Clinical and Translational Science
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Prior to the COVID pandemic, many CTSAs employed face-to-face interactions to conduct most of their community engagement (CE) activities. During the COVID pandemic, such engagement had to be curtailed and alternatives needed to be formulated. In addition, Community Engaged Research (CEnR) teams refocused their efforts to address this public health crisis. - Journal of Clinical and Translational Science
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COVID-19 altered research in Clinical and Translational Science Award (CTSA) hubs in an unprecedented manner, leading to adjustments for COVID-19 research. - Journal of Clinical and Translational Science
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The COVID-19 pandemic prompted the development and implementation of hundreds of clinical trials across the USA. The Trial Innovation Network (TIN), funded by the National Center for Advancing Translational Sciences, was an established clinical research network that pivoted to respond to the pandemic. 
August 11, 2022Patients previously hospitalized with COVID-19 had a 45% higher risk of heart failure than other hospitalized patients, according to the first national study of its kind, which was co-authored by a University of Arkansas for Medical Sciences (UAMS) researcher. Lead author Husam M. Salah, M.D., at UAMS said the findings reported in Nature Communications also revealed an even higher risk of heart
August 04, 2022CNBC: Grace McComsey, professor at the School of Medicine, discussed new research into “long COVID” in an effort to understand the mysterious condition. “You’ll be able to access a lot of data, lots of samples on patients that otherwise I can’t do from my own site. It will take me obviously a lot of time and a lot of resources that I don’t have,” McComsey said. Click here to continue reading this
August 02, 2022Lack of Inclusive Data and Low Trust Remain Barriers to Advancement of Health Equity On Thursday, June 16, 2022, the Clinical and Translational Science Collaborative (CTSC) hosted a REAL (Racial Equity and the Law) Talk webinar, titled Clinical Research Law and Policy, with the Cleveland Metropolitan Bar Association. Gelise Thomas, Assistant Director, Strategic DEI & Health Disparities with the
August 02, 2022Li’s Bold Hypothesis Helps Generate More Hypotheses in Fittech Xiao Li, PhD, is an Assistant Professor in the Department of Biochemistry and Member of the Center for RNA Science and Therapeutics in the Case School of Medicine and Assistant Professor in the Department of Biochemistry in the Case School of Medicine. Dr. Li combined her passion for science with a love for math and statistics as the-
June 23, 2022
Grace McComsey, MD, FIDSA, CTSC Principal Investigator, Vice President of Research and Associate Chief Scientific Officer at University Hospitals, and Professor of Pediatrics and Medicine at the CWRU School of Medicine, discussed new research that finds the risks of long COVID symptoms and new onset hypertension, diabetes and heart disease were lower among vaccinated patients with breakthrough
June 08, 2022The COVID-19 pandemic continues to present considerable public health challenges in the United States and around the globe. One of the most puzzling is why many people who get over an initial and often relatively mild COVID illness later develop new and potentially debilitating symptoms. These symptoms run the gamut including fatigue, shortness of breath, brain fog, anxiety, and gastrointestinal
June 06, 2022Episode Summary Early in the pandemic, Claire Decoteau, Iván Arenas their robust team of interdisciplinary researchers began to interview Black, Latinx, and white residents of three Chicago neighborhoods in order to explore how the pandemic has impacted different communities. Drawing on over 150 interviews with residents and policy makers, the team found that while COVID-19 has been treated as a
June 03, 2022A large randomized, placebo-controlled clinical trial led by the National Institutes of Health shows that treating adults hospitalized with COVID-19 with infliximab or abatacept — drugs widely used to treat certain autoimmune diseases — did not significantly shorten time to recovery but did substantially improve clinical status and reduce deaths. Some COVID-19 patients experience an immune
May 26, 2022SDoH are the non-clinical covariates of how people live, grow, learn and age and relates to how people manage stressors or prevent worsening health outcomes. Progressively, data about patient-level SDoH are collected using clinical screening tools for social needs and social risk factors. CD2H has led multiple SDoH synergistic initiatives relating to overall improvement of SDoH encoding and
-Pennsylvania State Univ Hershey Med CtrIn this seminar, Mary Frecker, PhD, and Greg Lewis, PhD, director and associate director of Penn State Center for Biodevices, will describe the Center’s approach toward fostering multidisciplinary research collaborations and the recommendations of a University-wide panel they have hosted on this topic. This seminar is for researchers interested in learning about cross-campus interdisciplinary
May 18, 2022Washington University School of Medicine in St. Louis has received a $61 million grant from the National Center for Advancing Translational Sciences of the National Institutes of Health (NIH) to support the infrastructure for developing and carrying out biomedical research studies. The funding supports Washington University’s Institute of Clinical and Translational Sciences (ICTS), which was
May 06, 2022Congratulations to Sara Auld, MD, MSc, who received the Albert E. Levy Award for Excellence in Scientific Research, junior faculty at Emory University. “I am so grateful for the wonderful colleagues and mentors I have had the pleasure of working with over the last several years,” says Dr. Auld. “As the saying goes, ‘chance favors the prepared,’ and my MSCR training allowed me to be prepared to
May 02, 2022As COVID-19 vaccines are approved for pediatric populations, a cross-collaborative effort between the USC School of Cinematic Arts, the Annenberg School for Communication and Journalism, and the Keck School of Medicine seeks to highlight the importance of getting vaccinated to protect yourself and your family. This successful collaboration resulted in the creation, production and dissemination of
April 29, 2022Assefa, a recent graduate of UVA, participated in the UVA-Historically Black Colleges and Universities Summer Research Bridge to Data Science program (Bridge) as a research fellow. This program is co-sponsored by integrated Translational Health Research Institute of Virginia (iTHRIV), the UVA School of Data Science (UVA SDS), Oracle, and Deloitte. According to the UVA SDS, the UVA-HBCU Summer
April 28, 2022Since 2007, the Institute of Translational Health Sciences (ITHS) has partnered with the University of Washington (UW), Fred Hutchinson Cancer Research Center, and Seattle Children’s on a Clinical and Translational Science Award (CTSA). This hub serves a large five-state region—Washington, Wyoming, Alaska, Montana, and Idaho (WWAMI)—encompassing rural and urban communities with unique health
April 28, 2022With hundreds of participating institutions—including all CTSA hubs—SMART IRB continues to facilitate reliance for multisite studies across the U.S., including more than 300 studies related to COVID-19. Investigators, study teams, and administrators at both reviewing and relying institutions can review the SMART IRB Agreement and access free resources on our website (www.smartirb.org). Next up
-Children's Research InstituteRegistration is now open for the 5th Annual Children's National Hospital - NIAD Symposium! The two-day hybrid symposium will feature current research related to COVID-19 and Autoinflammatory/Neuroimmune. All are invited to attend! This annual symposium celebrates the partnership between Children’s National Hospital and the National Institute of Allergy and Infectious Diseases (NIAID). Established
April 15, 2022A University of Arkansas for Medical Sciences (UAMS) team’s article on COVID-19 vaccine hesitancy recently received the 2022 Clinical and Translational Science Award from the American Society for Clinical Pharmacology & Therapeutics (ASCPT). The study, “COVID-19 Vaccine Hesitancy: Race/Ethnicity, Trust and Fear,” became the most downloaded paper in 2021 from ASCPT’s journal Clinical and
-University Of Miami School Of MedicineThe disruptions to social and economic life related to the COVID-19 pandemic have exacerbated factors known to elevate the risk of intimate partner violence (IPV) and created barriers to service availability for women currently experiencing it. This binational program of research comprised of scientists and community partners from Toronto, Chicago, and Miami helps address an ongoing need for
The Rapid Research Pilot Program (RP2) is designed to provide support for small, manageable research studies that focus on evaluating novel strategies for the implementation of COVID-19 testing in vulnerable and underserved populations. Researchers seeking funds to conduct COVID-19 testing can apply for up to $200,000 in direct cost funding and, if awarded, will have one year to complete the co
April 04, 2022Vanderbilt University Medical Center has competed successfully for a third five-year renewal of its Clinical and Translational Science (UL1) Award by the National Center for Advancing Translational Sciences. Initially funded in 2007, the renewal will provide more than $73 million for another five years to support the Vanderbilt Institute for Clinical and Translational Research (VICTR) and its
March 30, 2022The National Center for Data to Health’s National COVID Cohort Collaborative (N3C) Data Enclave houses the largest repository of COVID-19 data in the United States, with more than 4.5 million COVID+ patients. The N3C Data Enclave contains harmonized clinical data provided by more than 70 contributing health care institutions and consists of more than 14 billion rows of clinical information. The
March 08, 2022A new study published in the Journal of Infectious Diseases and led by Martin Zand, M.D., Ph.D., co-director of the University of Rochester Clinical and Translational Science Institute, shows that pre-existing immunity to the common cold may have put people at risk of more severe COVID illness and death. The study utilized the UR CTSI’s COVID Biobank to analyze antibodies in blood samples from
