University Of Illinois At Chicago

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    Center for Clinical and Translational Science

    The University of Illinois at Chicago (UIC) Center for Clinical and Translational Science (CCTS) seeks to catalyze translational research, locally and nationally, as part of a national network to improve individual and population health. Since our initial funding by the NIH in 2009, the CCTS has been a catalyst for mobilizing institutional support and resources to enhance clinical translational research and expand multidisciplinary training programs to increase workforce diversity and promote team science. The overarching goal—and driving focus—of the CCTS is to improve population health, particularly among minorities and underserved populations. Our high-quality multidisciplinary clinical and translational research, spanning T1-T4 and paired with strengths in community engagement and implementation science and appreciation for the social determinants of health, help to accelerate discoveries into practice and policy.
  • Amy Lasek, a former UIC Center for Clinical and Translational Science pilot grant awardee (2018-2020) and researcher at UIC’s Center for Alcohol Research in Epigenetics, was published in the journal Translational Psychiatry. The study, “Transcriptomics identifies STAT3 as a key regulator of hippocampal gene expression and anhedonia during withdrawal from chronic alcohol exposure,” builds on her

  • The Research Associate II, Clinical Research Center may assist with all studies supported through the Clinical Research Center. The Clinical Research Center (CRC) provides the UIC research community with a core of clinical research professionals. These individuals possess specialized training to provide a full array of clinical research services including, but not limited to: initial planning and
  • Researchers at the University of Illinois Chicago have identified a potent new antiviral compound that can effectively block viral replication in human cells. The discovery, spearheaded by the UICentre for Drug Discovery, could lead to the development of a new therapy to treat patients infected by SARS-CoV-2, the virus that causes COVID-19. The researchers say it could be a powerful new weapon in
  • In the hours after we die, certain cells in the human brain are still active. Some cells even increase their activity and grow to gargantuan proportions, according to new research from the University of Illinois Chicago. In a newly published study in the journal Scientific Reports, the UIC researchers analyzed gene expression in fresh brain tissue — which was collected during routine brain surgery

  • Several University of Illinois Chicago faculty members have addressed the issue of how to ethically conduct research with Black populations. In their paper “Ethics of Research at the Intersection of COVID-19 and Black Lives Matter: A Call to Action,” authors Natasha Crooks, an assistant professor, Phoenix Matthews, a professor, both of the UIC College of Nursing, and Geri Donenberg, director of
  • The SARS-CoV-2, the new coronavirus behind the current pandemic, infects humans by binding its surface-exposed spike proteins to ACE2 receptors exposed on the cell membranes. Upon a vaccination or a real infection, it takes several weeks before the immunity develops antibodies that can selectively bind to these spike proteins. Such antibody-labeled viruses are neutralized by the natural killer and

  • Manipulating the production of new neurons can improve cognition in animal models of the disease, raising the possibility that figuring out a way for humans to make more neurons could make a difference for people with dementia. Abby Olena, The Scientist Charlie Arber, a stem cell biologist at University College London, works with induced pluripotent stem cell models of inherited forms of dementia
  • The good news for women with HIV is that they appear to be no more vulnerable to menopause-related cognitive declines compared with other women.
  • Biomedical Informatics Senior Research Specialist UIC Center for Clinical and Translational Science The Biomedical Informatics Senior Research Specialist contributes to the conceptualization, design, development and delivery of biomedical informatics research projects, addressing all areas of clinical and translational science for the Center for Clinical & Translational Science (CCTS). This

  • Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR)

    Eosinophilic esophagitis, eosinophilic gastritis, eosinophilic gastroenteritis, and eosinophilic colitis are disorders in which a type of immune cell (called eosinophils) builds up in the digestive tract, causing gastrointestinal tissue damage. These disorders are painful, lifelong, and make it hard or impossible for people to eat many or all foods. The Consortium of Eosinophilic Gastrointestinal

  • Brain Vascular Malformation Consortium (BVMC)

    The Brain Vascular Malformation Consortium (BVMC) focuses on three rare brain conditions: familial cerebral cavernous malformation (CCM), Sturge-Weber syndrome (SWS), and hereditary hemorrhagic telangiectasia (HHT). These disorders are poorly understood, costly to manage, and can cause serious complications such as hemorrhages, seizures, and problems with spinal cord, nerve or brain function. Over

  • Story Transcript “It was not my intent to be involved at all, ever.” Bonnie Blue is Chicago’s first COVID-19 vaccine participant and one of more than 25,000 people who have volunteered for the Moderna vaccine trial so far. She didn’t intend to volunteer, but the rising death toll and an opportunity to save lives changed her mind. Blue says, “My people typically are not very trustful, but what I’m
  • University Of Illinois At Chicago

    About the Program

    The popular CIRTification program is now available for implementation at the institutional level. CIRTification is a free, web-based human research protections training program tailored specifically to the needs and roles of community research partners.

  • Today, a handful of Chicago residents will be the first in the city to participate in a national clinical trial to test a potential vaccine against SARS-CoV-2, the virus that causes COVID-19. The vaccine is an mRNA vaccine developed by Moderna, a Massachusetts-based biotech company. It is one of many vaccines in development but so far is one of the leading candidates being developed in the U.S
  • Story courtesy of CBS News Black Americans already face health disparities, but added pressure from the pandemic and social unrest is compounding stress for many. Dr. Olu Ajilore, an associate professor in the Department of Psychiatry at the University of Illinois at Chicago and Clinical Research Center director for UIC's Center for Clinical and Translational Science, joins CBSN’s Lana Zak to talk
  • One of the first synergy papers supported by the CLIC and CTSA consortium was published in the Journal of Clinical and Translational Science. Abstract: A primary barrier to translation of clinical research discoveries into care delivery and population health is the lack of sustainable infrastructure bringing researchers, policymakers, practitioners, and communities together to reduce silos in
  • The University of Illinois at Chicago Center for Clinical and Translational Science has released a free online version of its popular human research protection training program for community partners, CIRTification.
  • Drawing of a network on a global

    A leading cause of illness and death worldwide is Chronic Obstructive Pulmonary Disease (COPD), a group of lung diseases that make it difficult to breath. The COPD Outcomes-based Network for Clinical Effectiveness & Research Translation (CONCERT) is a consortium of six Clinical Centers and a Data Coordinating Center whose mission is to pool their expertise to ease the suffering caused by COPD. The

  • Drawing of a network on a global

    With an emphasis on educational issues and a goal of sharing resources, best practices and facilitating collaboration, members of the Midwest Consortium (MC) partner to strengthen clinical research education programs, mentoring, and career development opportunities for scholars. The Midwest Consortium for education and research collaboration began in 2006 with three Roadmap K12 institutions

  • Drug Discovery at UIC
    University Of Illinois At Chicago
    UICentre is a campus-wide small molecule drug discovery initiative at the University of Illinois at Chicago associated with the Center for Clinical and Translational Sciences (CTSA). Using established core instrumentation and with modest annual support, UICentre was conceived to utilize existing resources to leverage the expertise of scientist and clinicians teams across campus in collaborative
  • University Of Illinois At Chicago
    The goal of any community-academic research collaboration is equitable partnership. CIRTification teaches community research partners about the importance of protecting research participants while enhancing the overall contribution they are able to make to their respective research teams. In community-engaged research, academic researchers collaborate with different partners from non-academic