University Of Colorado Denver

Chief finding: Disease progresses faster in youth and adolescents than in adults A 15-year, multicenter study has changed the course of care for youth with type 2 diabetes, enhancing treatments for this growing population and illustrating the scope of the work conducted on the CU Anschutz Medical Campus. Called Treatment Options for Type 2 Diabetes in Adolescents & Youth (TODAY), the massive

The findings that appear in Lancet Infectious Diseases are from one of the first studies to examine the effectiveness of nirmatrelvir-ritonavir (Paxlovid) in non-hospitalized patients during an Omicron period of the COVID-19 pandemic that includes BA.4 and BA.5 subvariants. Though many Coloradans are proceeding as though the COVID-19 pandemic is over, the virus continues to circulate, evolve and

You probably learned about cilia in high school biology class. The tiny hairlike structures line our nasal passages, ears and airways. Children born with primary ciliary dyskinesia (PCD), a rare inherited disease, have problems with the cilia that prevent them from moving mucus and inhaled particles and germs out of their airways, causing mucus to build up, leading to ear, sinus and lung

Melissa Haendel, PhD, professor in the Department of Biochemistry and Molecular Genetics at the University of Colorado School of Medicine, and her team of data scientists have been working at a lightning-fast pace for two years, unlocking some of the mysteries of long COVID. Not only have they been instrumental in the development of the largest national, publicly available HIPAA-limited dataset in

Researchers are working to better prepare for the next pandemic. One of those researchers is Kevin Messacar, MD, PhD, an infectious disease expert and physician at Children’s Hospital Colorado and associate professor at the University of Colorado Anschutz Medical Campus. Messacar is leading an innovative, nationwide pilot study focusing on enterovirus D68, a virus that is linked to a rare polio

Ten years ago, people with cystic fibrosis (CF) celebrated when the FDA approved ivacaftor, the first drug designed to target the defective protein that causes the disease. CF is an inherited disorder that inflicts severe damage to the lungs, digestive system and other organs in the body. Since then, several additional drugs that use a similar mechanism have been approved by the FDA for CF. These

The massive volume of messages we all have received about COVID-19 led the World Health Organization to coin the term “infodemic”: too much information, including false or misleading messages, in digital and physical environments during a disease outbreak. Though academics will be studying the toll of this misinformation for many years to come, we know it has been massive. One way the National

The COVID-19 pandemic continues to present considerable public health challenges in the United States and around the globe. One of the most puzzling is why many people who get over an initial and often relatively mild COVID illness later develop new and potentially debilitating symptoms. These symptoms run the gamut including fatigue, shortness of breath, brain fog, anxiety, and gastrointestinal

The National Institutes of Health (NIH) has invested nearly $470 million to build a national study population of diverse research volunteers and support large-scale studies on the long-term effects of COVID-19. The Colorado Clinical and Translational Sciences Institute (CCTSI) is playing a major role in the initiative called REsearching COVID to Enhance Recovery or RECOVER. Many of us know someone

As the country rides a new wave of the COVID-19 pandemic, it faces a riptide that’s threatening its course. The delta variant, the now-predominant strain of coronavirus, prompted President Joe Biden’s call for booster shots for all vaccinated adults on Aug. 18 and underscored discussions at a research summit that ran parallel to the president’s nationwide address. “This is, of course, something

In March of 2020, the pandemic drove Coloradans to enter lockdown mode. This was no different for researchers on the CU Anschutz Medical Campus. The result was that research operations were completely shuttered unless they were related to COVID-19 or essential to patient care. A group of researchers from across the country wanted to learn how different institutions handled closing research down

Findings from a new study published in the New England Journal of Medicine underscore the importance of early, intensive treatment for youth-onset type 2 diabetes. Phil Zeitler, MD, PhD, has been treating youth with type 2 diabetes for more than 20 years. He and a team of researchers published a paper today on the TODAY2 study in the New England Journal of Medicine on the long-term complications

The CCTSI responded to the pandemic by issuing a rapid-release RFA to address COVID-19. CCTSI leaders called it the COVID-19-Rapid Research Pilot Program. They released the RFA on Monday evening, March 30 and closed the application process just four days later. This new pilot grant program supported the development of novel diagnostic and treatment methods and innovative technologies related to

Adit Ginde, MD, and the Colorado Clinical Translational Sciences Institute team are spreading the word about monoclonal antibody treatment for COVID-19. As the COVID-19 pandemic continues to lurk in many communities, aided by vaccine hesitancy and the emergence of disease mutations like the Delta variant, physicians are still looking for effective ways to treat those who test positive for the

In vaccine clinical trials, the Pfizer and Moderna COVID-19 vaccines were shown to be about 95% effective in preventing COVID-19. Now a study from the Centers for Disease Control and Prevention uses real-world data to show that indeed, those who are 65 years and older who are fully vaccinated are 94% percent less likely to be hospitalized for COVID-19 than those who have not been vaccinated

Dr. James Feinstein, a pediatrician who has dedicated his career to treating children with complex chronic conditions and severe neurological impairments, has developed a tool so parents may easily and comprehensively report their child’s symptoms. He has just published his research on this topic in JAMA Pediatrics and in JAMA Open.

The nation has been coping with the pandemic for more than a year, and in this time, researchers have learned a great deal about how to treat COVID-19. Yet they have also been faced with what they still must learn, including how to reach the individuals who have been most dramatically impacted by the disease and who could benefit the most from new treatments. A new $8.7 million grant from the