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The Miami Clinical and Translational Science Institute (CTSI) mourns the passing of its Director and MPI Ralph L. Sacco, M.D., M.S., a highly respected and beloved member of the UHealth and University of Miami Miller School of Medicine community, on January 17, from a glioblastoma. Dr. Sacco’s outstanding achievements and contributions in research, teaching and mentorship, and patient care made a lasting impact on health care in South Florida, the nation, and the world.